How DNA testing is reuniting families after decades apart
BY Sarah Treleaven
18th Sep 2023 Life
8 min read
Advances in DNA testing and genealogy kits are reuniting families with members who have been lost for decades. Here's some stories of exactly how this happening
Melissa Highsmith
In 2018, Jeff Highsmith of Texas started a
Facebook page on behalf of his family. The page
had one objective: to find Melissa Suzanne
Highsmith, Jeff’s sister. At just 21 months, she
had been abducted from Fort Worth by her
babysitter 51 years earlier and the family was
desperate for answers.
Melissa Highsmith's baby photo was used alongside age-progression photos on a flyer. Credit: Jeff Highsmith
In addition to the Facebook page, they made
flyers with baby Melissa’s face and age-
progression photos that indicated what she might
look like now, in her fifties. Remarkably, they were
convinced she was still alive all these years later,
and determined to be reunited with her.
They knew that more tools were now
available to help locate missing persons—
such as genealogy kits with DNA tests. And
so, the family bought kits from 23andMe, and
then uploaded the results to a public database
called GEDmatch.
It seemed like a shot in the dark, but it worked.
In November 2022, the Highsmith family found
Melissa through a key DNA match: Melissa’s
daughter. By pulling the threads of DNA matches,
triangulating connections on a much bigger
family tree, they zeroed in on the baby snatched
so long ago. The family reunion was a joyful one.
Melissa described being found as “the most
wonderful feeling in the world.”
The story of Melissa Highsmith and her family
got global news coverage. But it’s only one of
many cases of people being connected by DNA
analysis. In Canada, siblings separately adopted
from Romania when they were babies
were reunited in their fifties when both
took a DNA test to learn more about
their biological health; turns out they
had spent much of their lives within a
30-minute drive of each other. And two
sisters—one in the UK, the other in the
Netherlands—met for the first time in
75 years after learning that they have
the same father.
Many other missing persons cases
There are countless stories. In Spain,
a DNA database has been set up to
identify the “stolen babies” of the
Franco dictatorship. Black Americans
are using DNA tests to learn about
family lineages disrupted by slavery.
And stories about recent tragedies—
including the devastating February
earthquake in Syria and Turkey—have
included details about how DNA was
being used to reunite children with
their parents.
Much of the news coverage of DNA
technology advances has focused on
capturing a killer or identifying a long-dead victim. But there’s another,
equally compelling possibility: solving
cold cases involving a living victim or
missing person. In other words,
someone out in the world, location
and identity unknown, who can be
made aware of who they really are only
through DNA.
"DNA tehcnology advances can help solve cold cases involving a living victim or missing person"
Police forces have stepped up efforts
to utilise it, and private businesses
have also hopped on board, creating
databases and putting the tools for
DNA collection into the hands of
consumers. Crucially, there’s also been
a rise in citizen sleuths and
investigative genetic genealogists,
perhaps bolstered by our insatiable
love for true crime, who are helping to
bring ordinary families together again.
Major advances in forensic DNA
According to Michael Marciano,
director of research for the Forensic
and National Security Sciences
Institute (FNSSI) at Syracuse
University’s College of Arts and
Sciences in New York, there have
been major advances in recent
decades in how forensic DNA
analysis is done. One has to do with
sensitivity: our ability to detect lower
amounts of DNA than ever before.
That means researchers can now
identify the DNA that’s deposited
from someone touching an object or
a person.
It also means that mixed DNA
samples (including more than one
person’s DNA) can be disentangled.
“For example, a perpetrator enters a
bank, picks up the pen where you fill
out your deposit slips, writes a note
and gives it to the clerk,” says
Marciano. “We know the perpetrator
picked up the pen, but how many
other people did? Their DNA might be
on it too.” Now it’s easier to isolate the
perpetrator’s genetic material.
The second major development has
to do with how results are analysed.
Software and computing power have
improved sufficiently that we can
create better models and more
accurate statistics that help analysts
interpret the samples they’ve collected.
But still, to get a match, researchers
must be able to link a sample to a DNA
profile. “Forensics is about
comparisons,” says Marciano. “If I have
a fingerprint or DNA profile but
nothing to compare it to, I can’t
determine whose it is.”
DNA databases
This is where databases of DNA
profiles come in. Sometimes, those
profiles are derived from court-mandated samples or samples
collected from crime scenes or missing
persons cases. Dean Hildebrand runs a
forensics lab at BC Institute of
Technology in Canada, and for
decades he has done work for the
government coroner service, running
DNA samples that primarily come
from missing persons or their families.
Some are from remains found at
scenes. Other times, he runs samples
from the belongings of a missing
person—a blanket the person couldn’t
sleep without, or a pair of broken
glasses left behind.
“We have an avalanche of those
samples coming through all the
time,” says Hildebrand. Many are
attached to long-cold cases. More
than a decade ago, Hildebrand
helped develop a missing persons
database so police officers can log
unidentified remains and the
samples from missing persons.
DNA analysis as a game
But Lately, DNA searching has had
little to do with foul play. Companies
such as Ancestry.com, 23andMe,
FamilyTreeDNA and MyHeritage have
sold consumers on the idea of
uncovering their heritage and making
connections. It’s DNA analysis as a
party game for the whole family.
And it’s very popular. By the start of
2019, according to MIT Technology
Review, more than 26 million people
had sent their DNA to one of four
commercial ancestry and health
databases on the market.
"Twenty years ago, we couldn't simply spit in a tube and get a report on our family lineage"
These products and their analysis
are the result of technological
advancement; 20 years ago, it
wouldn’t have been possible for you
and your family to spit in tubes, put
them in the post, then receive a report
on your lineage. But they also reflect a
growing social phenomenon: a
fascination with drawing connections
and insights into the self through the
use of genetic material.
“When you have a lot of good
quality DNA, you can capture a lot of
information about an individual,” says
Nicole Novroski, assistant professor in
the department of anthropology at the
University of Toronto. She says that
the databases of private ancestry or
genealogy kit companies really grew,
and then came the option to put your
DNA sample on public databases
allowing people to make additional
connections as well.
Armchair detectives
GEDmatch is one such public
database. It allows users to compare
samples across a broader spectrum
than a single site, looking for matches
with overlapping genetic material. The
bigger the overlap, the more likely the
match is a close relative, like a parent,
child, grandparent or first cousin.
“Sometimes, it’s a dead end,” says
Novroski. “But the more people in the
database, the more potential there is
to make a connection, even if it’s a far-out one. Then it’s the genealogists’
and the investigators’ job to kind of
rebuild all that missing information
together for these big family trees or
kinship determinations.”
Novroski says that the work of
armchair detectives, uploading
samples and combing through DNA
matches, can yield a mixed bag of
implications. “It’s doing a lot of good
by solving cold cases,” she says. “But
some people don’t like the
information they find, especially
when there’s been infidelity and
things of that nature that were
previously not known or discussed.”
Guo Xinzhen
Guo Xinzhen back together with his parents, 24 years after he was abducted at age two. Credit: China Daily via Reuters
The number of public and private
databases for genetic identification is
growing. In China, authorities keep a
database that includes the DNA of
parents of missing children, and of
any children found by police. The
system was thrust into the
spotlight in 2021 when a family
was reunited with their kidnapped
son after 24 years—a case that also
drew attention to the devastation
of living with the uncertainty of a
loved one’s disappearance.
Before the family was reunited,
the son’s father, Guo Gangtang,
spent years criss-crossing the
massive country in his
determination to find his son, Guo
Xinzhen, often sleeping outdoors
and travelling by motorbike with flyers
and a flag displaying his son’s image.
Without the help of DNA, he likely
would never have found his son.
According to Chinese media,
thousands of missing children have
been found thanks to the database.
Investigative Genetic Genealogy
The desire to connect with family
members, missing or not yet
discovered, has given rise to another
phenomenon: Investigative Genetic
Genealogy (IGG). IGG takes all the
newly public DNA information being
uploaded to genealogy websites and
combines it with other sources of
public and private data—such as
Facebook profiles, marriage records
and even worn paper copies of family
trees—to infer relationships and build
out networks of people.
"IGG takes newly public DNA information on genealogy websites and combines it with data like Facebook profiles and marriage records"
It’s as much a social phenomenon as
a technological one, and a wave of IGG investigators are now working in
tandem with families and law
enforcement to find missing persons
and solve long-standing mysteries.
One famous recent example is when
an IGG investigator, a retired solicitor
with a PhD in biology named Barbara
Rae-Venter, helped police track down
California’s “Golden State Killer,” who
had eluded authorities for decades, by
combing through DNA of the killer’s
distant relatives.
Rosemarie Döderlein
But IGGs are also being consulted to
help families find long-lost relatives. In
March 2022, Christa Hastie decided to
help her mother, Vera, age 80, solve a
family mystery: what had happened to
Vera’s sister, Rosemarie, when she
vanished from the streets of Montreal
one winter day in 1954 at the age of 14?
Over six months, Vera and Christa
searched for information related to
Rosemarie’s disappearance.
Christa already had a DNA profile
on Ancestry, and now she added
profiles to other major sites. She also
got an investigative genealogist to
help her zero in on maternal
matches. They found a DNA match
close enough to be Rosemarie’s
grandchild, but when Christa
reached out to the person, they
claimed not to know Rosemarie.
Since Vera was born in Germany,
she and Christa enlisted the help of a
genealogist with experience in DNA
testing in that country. Carolin Becker
put Vera’s grandmother’s surname into
a database she had constructed, and
her software found nine generations of
ancestors. “A whopping 34 pages of
tiny text,” says Christa.
Becker cross-referenced the data
with matches from DNA sites, ruling
out anyone who wasn’t both a
maternal and paternal match to Vera.
And she helped Christa and Vera reach
out to long-lost relatives, adding their
DNA to the family tree and bolstering
the search.
Ultimately, more than 900 people
fleshed out that family tree, dating to
the 17th century. Using DNA Painter, a
website with geneology research tools,
Christa was able to re-confirm the
specific match: Rosemarie’s
granddaughter, who had been
identified before.
Christa reached out again, this time
with proof, and Christa and Vera
connected with Rosemarie’s whole
family. The truth was astonishing:
Rosemarie had died years earlier, but
her life hadn’t ended when she
disappeared all those decades ago; she
went on to have children and
grandchildren. So while there would
be no reunion, no explanation for
Rosemarie’s disappearance, knowing
she had not been murdered was a
huge comfort to Vera.
There was another upside to their
search: because the IGG helped them
map out a comprehensive family tree,
they were united with or introduced
to relatives they now keep in touch
with. Christa and Vera emerged from
this exercise with an expanded sense
of family.
The dark side of DNA testing
That’s exactly the promise of
commercial DNA sites. And it’s easy to
imagine any number of positive
outcomes. We now have the capability
to reunite lost family members
separated by war or other
circumstances. We can pinpoint the
ancestral homes of adoptees or others
whose biological connections have
been severed.
But now imagIne a less rosy scenario: a
family tries DNA kits as a fun activity,
swabbing the inside of their cheeks
while standing around the dinner
table, and then eagerly awaits the
results—only to have those kits show,
unexpectedly, that one of the kids is
not a biological match. “The more
information we’re collecting from our
DNA, the more we open this Pandora’s
box of ethical considerations,” says
Hildebrand. “Because there can be big
surprises awaiting—some of them
really great, and some shocking.”
"The more information we’re collecting from our DNA, the more we open this Pandora’s box of ethical considerations"
The privacy implications can also
be astounding. At least one consumer
site (GEDmatch) now has an opt-in
clause allowing what you upload to be
searched by both the police and the
public. Since DNA is shared between
biological family members, if a
relative uploads theirs to one of these
sites, they are potentially implicating
you as well, because their DNA is
obviously linked to yours. So anyone
who wants to, say, anonymously
donate sperm or give up a baby for
adoption could one day be
identified—even if they never actually
provide their own DNA sample.
“I think it’s a very powerful thing,”
says Hildebrand, adding that if only
around ten per cent of people add
their DNA samples into one of these
public or private databases, we would
be able to identify every single human
on Earth.
And that comes with benefits and
drawbacks. “As people get more into
this, we’ll be closer to the point where
you pretty much can’t hide,” he says.
“It’ll be possible to link every family in
the world.”
For the Highsmith family, who were
happily reunited in Texas after
decades apart, DNA was the link. “Our
finding Melissa was purely because of
DNA, not because of any police/FBI
involvement, podcast involvement, or
even our family’s own private
investigations or speculations,” notes
one Facebook update. “DNA WINS
THIS SEARCH!”.
Banner credit: Illustration by Nikki Ernst
Banner credit: Illustration by Nikki Ernst
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